Salicylate Toxicity from Genital Exposure to a Methylsalicylate-Containing Rubefacient

Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard.

The adverse effect of topical methylsalicylate ointment on warfarin anticoagulation is studied in 11 patients. All patients had an abnormally elevated international normalized ratio after significant usage of topical methylsalicylate ointment as obvious from both the clinical history and a positive blood level of salicylate. Out of the 11 patients, 3 had bleeding manifestation; 2 with bruises a...

Silica-titania xerogel for solid phase spectrophotometric determination of salicylate and its derivatives in biological liquids and pharmaceuticals

BACKGROUND Salicylic acid and its derivatives are widely used drugs with potential toxicity. The main areas of salicylate derivatives determination are biological liquids and pharmaceuticals analysis. RESULTS Silica-titania xerogel has been used for solid phase spectrophotometric determination of various salicylate derivatives (salicylate, salicylamide, methylsalicylate). The reaction conditi...

Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.

AIMS The penetration of active ingredients from topically applied anti-inflammatory pharmaceutical products into tissues below the skin is the basis of their therapeutic efficacy. There is still controversy as to whether these agents are capable of direct penetration by diffusion through the tissues or whether redistribution in the systemic circulation is responsible for their tissue deposition...

The cardiomyopathy associated with methylsalicylate.

Blistering eruption following a rubefacient rub for shoulder discomfort.

Annals Academy of Medicine Dear Editor, A 96-year-old woman was referred as an emergency with a suspected allergic reaction to Deep Heat® rub (Mentholatum Company Ltd, East Kilbride, Scotland). Five days before referral, she developed pain and stiffness of her left neck and shoulder. Because of this discomfort, assumed to be muscular, she started applying an over-the-counter rubefacient,1 calle...